Hey folks, has anyone had experience with the drug Fenofibrate?
To back up a bit, I have been on what I call a “tour de speculative PSC drugs” over the last 2 ½ years to try and get my alkaline phosphatase down. It has been elevated and increasing since about 2010, and peaked at 500 early this year. I tried URSO and then oral Vancomycin, neither of which had an effect. I started Fenofibrate in March and have had four rounds of labs since, with steadily decreasing levels - the latest being 256.
Now I am far from concluding (or even allowing myself to hope) that my Alk. Phos. levels will go or stay lower and, there is probably not any data out there showing enzymes reduced as a result of Fenofibrate will improve my outcome. That said, the big reduction in my Alk. Phos. level so far is definitely better than a sharp stick in the eye.
As I understand, Fenofibrate is a peroxisome proliferator-activated receptor alpha (PPARα) agonist. Did that help anyone?? Didn’t think so. I have not been able to make much sense of it, and I’m a dang scientist. If you want to get into the theoretical jungle, try this article: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4515188/. I will be glad to explain it to you in a few years after I receive a degree in cellular biology and another in genetics.
So, circling back…does anyone have any input or want to share their experiences with Fenofibrate (good, bad or otherwise)? Could it be one of those drugs that has potential and should be investigated further? I do know that this drug has been used for decades to lower cholesterol so the side effects are well documented and, apparently, are mild if any for most people.
Take care. Be well.