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Primary Sclerosing Cholangitis (PSC) - Online Support Group

FMT in PSC (pilot trial)


#1

Fecal Microbiota Transplantation in Patients With Primary Sclerosing Cholangitis: A Pilot Clinical Trial.

RESULTS: Ten patients underwent FMT. Nine patients had ulcerative colitis, and 1 had Crohn’s colitis. The mean baseline ALP level was 489 U/L. There were no related adverse events. Overall, 30% (3/10) experienced a ≥50% decrease in ALP levels.

https://www.ncbi.nlm.nih.gov/m/pubmed/30730351/


#2

Encouraging progress. Thanks for the update Ted.


#3

I’ve read of a few whom have tried this to no avail.
There are studies out there … but

Not saying it’s not a possible viable option, but certainly it seems to be, per what I’ve read from others, very hit and miss.


#4

While this is a small group of patients from which to draw conclusions, FMT appears to be an alternative means to achieve a shift in fecal microbiota. It has previously been hypothesized that probiotics may be able to play a similar role in PSC, though a variety of studies suggest no consistent and clear consequence of their use, likely secondary to a variety of treatment durations and varying compositions of probiotics [81]. FMT may more easily and directly affect microbiota than probiotics in PSC. A recent clinical trial at Brigham and Women’s Hospital in the USA evaluated the impact of FMT in PSC patients. The study’s primary outcome measures include genotyping and a comparison of recipient microbiota before and after FMT in addition comparison with the donor’s microbiota. Liver chemistry was measured over 3 months, with success defined as a 50% reduction in the levels of ALP, alanine transaminase, aspartate aminotransferase, and total bilirubin. This study concluded in April 2017

From this article - love ncbi for data


#5

The authors concluded that FMT in PSC patient is safe. I agree with this one but not sure about anything else since I haven’t read the full article yet. One critical information I want to know is that how the authors can contribute all those changes to be effects of one single FMT two years ago.