I'm not sure how many others are on Ursodiol, but I got some rather alarming news from my GI Doctor today.
I'm in the early stages of PSC (after having had Ulcerative Colitis for close to 25 years). One of the drugs I was prescribed after diagnosis of the PSC is Ursodiol. My routine with this drug has been three 500 Mg tablets daily (1.5 tablets twice a day).
After my latest blood test last week, I received the results with all being pretty steady and right around the same levels of my last checkup with the exception of Alkaline Phosphate, which jumped from 279 to 336 (normal range is 37-117).
My Doctor tried to reach me yesterday, but was too busy at work to take his call so he reached me this morning.
His advice was stop Ursodiol immediately! He explained further testing on the drug has shown that in large doses it not only does not help stop or subside PSC from getting worse, but may actually increase the damage to the liver. Pretty alarming.
I've asked him for the links to the studies he informed me of, and will post when I receive them. A little disheartening to think that a drug you thought might be helping you stave off the damage of the disease may have made it worse!