I did have a trial on myself, total twice, one success and another one nothing.
My symptoms are quite predictable once they started. I will see dark urine and full jaundice for about 1-2 months. Then everything goes back to normal. It happens usually twice a year. First time when I'm sure the jaundice is going up, I started Flagyl and urine went back to normal color in 2 days. Next time, it happened again, Falgyl did nothing.
That does not seem a surprise to me. PSC is too complicated.
Don't try it yourself unless you know what you're doing.