I created this post to share THIS interesting article I just discovered. This study has conducted research on both mice and humans, which suggests that histamin might accelerate PSC-progression as well as bile duct cancer (CCA) progression. The authors have discovered that common over-the-counter antihistamines can reverse PSC-associated damage to the bile ducts and liver. They have also discovered that it can slow down CCA progression.
The results from the study are especially interesting since antihistamines are cheap over-the-counter drugs, with very few side effects. Too be fair, only 3 human PSC patients and 6 CCA patients have been treated. Therefor more research is of course needed. Keep in mind that the real problem with this discovery is actually the fact that antihistamines are cheap over-the-counter drugs. Because of this, no pharmacutical company is ever going to sponsor any clinical trials.