I had gotten 23AndMe done back in 2013. At the time, I didn’t see anything related to PSC, but I downloaded my data and ran it through Promethease a few weeks ago, which for a $10 fee, pulls in info from various research papers and SNPedia. It turns out I might have some markers.
This was done with an old version of 23AndMe (chip version 3). I don’t know what the current version covers, but here’s what I found:
rs3197999 - https://www.snpedia.com/index.php/rs3197999 - mine is T;T
rs12612347 - https://www.snpedia.com/index.php/rs12612347 - mine is A;G
rs9524260 - https://www.snpedia.com/index.php/rs9524260 - mine is A;G
I don’t have any data on rs3099844 or rs2844559, but those might also be associated with PSC. This article has some info: https://www.gastrojournal.org/article/S0016-5085(09)02063-0/fulltext
There are also some SNPs associated with CA19-9 (a tumor marker) production on the FUT3 gene. It looks like rs2306969, rs28362459, rs3745635 are places to look at. Unfortunately, I don’t have any data on those. There’s a chance that some people don’t produce CA19-9, which seems kind of important if a doctor is using CA19-9 to monitor for cancer.
Does anyone else have any data or experience analyzing stuff like this? I’m really curious what these data mean, and I just barely understand what I’m looking at.
Thanks and stay safe,