Last week I was started on Ursodiol after a severe cholangitis attack. I presented to the ER with a 102.5 fever, severe right upper quadrant (RUQ) abdominal pain, and nausea. We’d treated previous attacks of pain and nausea alone, no fever. My bile wasn’t moving through my hepatic ducts due to classic PSC beading strictures.
I received IV antibiotic Zosyn while hospitalized for 5 days. My hepatologist visited me daily to review MRCP and ERCP findings. He started me on Ursodiol 300mg three times daily, a low dose. I had soft stool on it with gas for 8 days that finally improved. I was diagnosed finally in 2016 after many years of symptoms. I also have autoimmune hepatitis, AIH, and other coexisting conditions.
What is your experience on ursodiol long term and short term for your PSC?