We have been using ANI 2x250mg 3 times a day after meals to a total of 1500mg per day for my 6 year old son during the past 3 and half months. After the first month we saw good improvements with AST/ALT/GGT/ALP around 71/81/198/541, the lowest ever we have seen in a year. But the next 2 months, these went up to 133/263/731/343 and 119/161/591/195 unfortunately although there have been some other improvements after switching to vanco.
He had abdomen distention earlier and that went away completely. He had some veins showing up from the chest towards the abdomen and those mostly went away too. He has more energy compared to earlier, and after a year of no change in growth, finally had a growth spurt last couple of months in height and grew couple of inches. Vitamin D and PT/INR are in control without any supplements and bilirubin has been under <= 0.3 mg/dL. Before this we were on urso/aza/prednisone from Feb of this year and the numbers were a lot higher last year when we were diagnosed incorrectly as wilson’s disease and were using different medication(s).
We are stumped for sure and doctor thinks because of kids fast metabolism the medicine may not have enough time in the stomach to do its work. Doc recommends us to switch to liquid vanco now and finally its approved from insurance today after a month of back & forth. We have to see if this makes any difference to LFT. At the back of our mind, we are wondering if the diagnosis of PSC (actually we were told its early stages of ASC after the MRCP in Feb 2019) is correct.